Guardian needs to be your first choice in box gloves and isolator glove manufacturers. The gloves are USA made. They are used in numerous industries ranging from the Nuclear Industry, Pharmaceutical Industry, Clean Rooms, and they have even been used to protect first responders from containments when working on someone after they have been exposed to toxic agent. The Guardian box gloves are made from Butyl and Neoprene and soon we will be offering CSM. We also are launching the largest production capacity for long gloves in the glovebox industry!